Donor screening for human T-cell lymphotrophic virus 1/2: changing paradigms for changing testing capacity.

نویسندگان

  • D R Kaul
  • S Taranto
  • C Alexander
  • S Covington
  • M Marvin
  • M Nowicki
  • J Orlowski
  • C Pancoska
  • T L Pruett
  • M G Ison
چکیده

Organ Procurement and Transplant Network (OPTN) policy currently requires the testing of all potential organ donors for human T-cell lymphotrophic virus (HTLV)-1/2. Most Organ Procurement Organizations (OPO) use the Abbott HTLV-I/HTLV-II Enzyme Immunoassay (EIA). This assay will no longer be manufactured after December 31, 2009; the only commercially available FDA-licensed assay will be the Abbott PRISM HTLV-I/II assay which poses many challenges to OPO use for organ donor screening. As a result, screening donors for HTLV-1/2 in a timely manner pretransplant after December 31, 2009 will be challenging. The true incidence of HTLV-1 in United States (U.S.) organ donors is not well described but appears to be low ( approximately 0.03-0.5%). HTLV-1 is associated with malignancy and neurological disease; HTLV-2 has not been convincingly associated with disease in humans. Donors that are HTLV-1/2 seropositive are infrequently used despite most results being either false positive or resulting from HTLV-2 infection. There is urgent need to encourage the development of assays, instruments and platforms optimized for organ donors that can be used to screen for transmissible disease in donors; these must have appropriate sensitivity and specificity to identify all infections while minimizing organ loss through false positive testing.

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عنوان ژورنال:
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

دوره 10 2  شماره 

صفحات  -

تاریخ انتشار 2010